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Do Weight Loss Supplements Work?

o Weight Loss Supplements Work? written in text with image of pills and measuring tape.

Do Weight Loss Supplements Work?

Do Weight Loss Supplements Work? written in text with image of pills and measuring tape.

Do weight loss supplements work?

To answer your question, let’s just put it like this…⁣

There’s nothing on God’s green earth that’s going to lose weight for you if you’re not in a calorie deficit. And if you are in one, what’s the point of taking something to do what the deficit is already doing, which is making you lose weight?

Nevertheless, because you have your mind made up on shelling out cash for shit you don’t need, below is a list of some of the popular weight loss substances for you to choose from.

Caffeine

Caffeine is a stimulant found in coffee, tea, and energy drinks. It’s also a popular ingredient in weight loss supplements for its thermogenic, or fat burning, properties, which is supported by research.1In a study of 76 obese women, those with higher caffeine intake saw a greater reduction in weight, waist circumference, and fat mass than those with lower caffeine intakes. For more info, see Westerterp-Plantenga, Margriet, et al. “Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation.” Obesity Research, vol. 13, no. 7, Jul. 2005, pp. 1195–1204. Another claim is that it helps suppress the appetite. Studies suggest that caffeine’s effect on calorie intake isn’t significant and that minimal effect is only in people who don’t normally consume caffeine. Moreover, the effect disappears once a tolerance is built up.2Panek-Shirley, Leah, et al. “Caffeine Transiently Affects Food Intake at Breakfast.” Journal of the Academy of Nutrition and Dietetics, vol. 118, no. 10, Oct. 2018, pp. 1832–1843.

Garcinia Cambogia Extract

Garcinia cambogia is derived from a tropical fruit of the same name. The juice from the fruit contains hydroxycitric acid, which is said to inhibit citric acid lyase, a fat-producing enzyme. It’s also purported to suppress appetite. There’s nothing in the scientific literature that supports either claim.3Refer to Heymsfield, Steven, et al. “Garcinia Cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent: A Randomized Controlled Trial.” JAMA, vol. 280, no. 18, 11 Nov. 1998, pp. 1596–1600. Also see Chuah, Li, et al. “Updates on Antiobesity Effect of Garcinia Origin (−)-HCA.” Evidence-Based Complementary and Alternative Medicine, vol. 2013, 6 Aug. 2013.

Chitosan

Chitosan is a sugar taken from the shells of crabs, lobsters, and shrimp. It’s supposed to bind to fats in the digestive tract so your body can’t absorb them. Research suggests that taking it results in a reduction in weight loss but that effect is very small and isn’t of clinical significance.4Mhurchu, CN, et al. “Effect of Chitosan on Weight Loss in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials.” Obesity Reviews, vol. 6, no. 1, Feb. 2005, pp. 35–42.

 

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Pyruvate

When the body breaks down sugar, it produces pyruvate, a molecule that’s then used to provide further energy along the Krebs cycle.5The Krebs cycle is a series of chemical reactions that occur in organisms that require oxygen and is part of the process of releasing stored energy from carbohydrates, fat, and protein. As a supplement, it’s supposed to boost fat breakdown. Based on evidence from several studies, its effect on weight loss is weak.6Onakpoya, Igho, et al. “Pyruvate Supplementation for Weight Loss: A Systematic Review and Meta-analysis of Randomized Clinical Trials.” Critical Reviews in Food, Science, and Nutrition, vol. 54, no. 1, 2014, pp. 17–23.

Green Tea Extract

Made from dried green tea leaves, green tea extract contains caffeine and plant compounds called catechins, including epigallocatechin-3-gallate (EGCG). The extract is said to help increase thermogenesis, or fat burning. Some studies indicate that it does help with weight loss, especially with the reduction of fat around the stomach.7Maki, Kevin, et al. “Green Tea Catechin Consumption Enhances Exercise-Induced Abdominal Fat Loss in Overweight and Obese Adults.” Journal of Nutrition, vol. 139, no. 2, Feb. 2009, pp. 264–270. Other studies suggest that what effect tea catechins have on weight loss is minimal, if any.8Phung, Olivia, et al. “Effect of Green Tea Catechins With or Without Caffeine on Anthropometric Measures: A Systematic Review and Meta-Analysis.” American Journal of Clinical Nutrition, vol. 91, no. 1, Jan. 2010, pp. 73–81.

Conjugated Linoleic Acid (CLA)

Conjugated linoleic acid (CLA) is a fatty acid that can be obtained from meat and dairy and is marketed as being able to decrease appetite, increase the breakdown of fat, boost thermogenesis, and hinder the body’s ability to store fat. If you’re not an animal, then the claims about its ability to do all those things are dubious, as weight loss is far less in human studies.9Jeukendrup, AE, Randall, R. “Fat Burners: Nutritional Supplements that Increase Fat Metabolism.” Obesity Reviews, vol. 12, no. 10, Oct. 2011, pp. 841–851.

By no means is the above list exhaustive. There are many, many more ingredients touted as helping to achieve weight loss.10e.g. forskolin, carnitine, capsaicin, lecithin, calcium, choline, chromium picolinate, fucoxanthin, ephedra, hydroxycitrate (HCA), lipase, inositol, taurine, leucine, yohimbine, clenbuterol, 7-keto DHEA, raspberry ketone, etc. From the quick survey, though, you should be able to pick up on the running theme, one that applies to virtually every weight loss supplement on the market.

And that is?

*sigh*

That theme is that whatever weight loss pill there is that’s said to work has very little effect on weight loss, if there is any.11So if nothing really works, what are you supposed to take then? If you’re clinically obese or have obesity-related health complications, then consult with your physician to get a prescription for one of several weight loss drugs approved for medical use by the FDA. These drugs are liraglutide (Saxenda), lorcaserin (Belviq), naltrexone-bupropion (Contrave), orlistat (Xenical or Alli), semaglutide (Wegovy), and phentermine-topiramate (Qsymia).

NOTE: The generic drug name is followed by the brand name in parentheses.

*sigh*

Glossary: caloric deficit, calories, dietary fat, fat, supplement


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